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論文リスト

doi title author source_title year
2143 10.1002/minf.202000028 Molecular Informatics 2020
3744 10.1016/j.bmcl.2020.127377 The Sars-Cov-2 Main Protease As Drug Target Ullrich, Sven, 0000-0003-4184-7024; Nitsche, Christoph, 0000-0002-3704-2699 Bioorganic & Medicinal Chemistry Letters 2020
7988 10.1016/j.lfs.2020.117627 Virtual Screening And Repurposing Of Fda Approved Drugs Against Covid-19 Main Protease Kandeel, Mahmoud; Al-Nazawi, Mohammed Life Sciences 2020
11043 10.1021/acs.jcim.0c00575 Sars-Cov-2 Main Protease: A Molecular Dynamics Study Suarez, Dimas, 0000-0001-8003-2309; Diaz, Natalia, 0000-0002-9641-7630 Journal Of Chemical Information And Modeling 2020
11056 10.1021/acs.jmedchem.0c01063 Discovery Of Ketone-Based Covalent Inhibitors Of Coronavirus 3Cl Proteases For The Potential Therapeutic Treatment Of Covid-19 Hoffman, Robert L., 0000-0002-2030-9094; Kania, Robert S.; Brothers, Mary A.; Davies, Jay F.; Ferre, Rose A.; Gajiwala, Ketan S.; He, Mingying; Hogan, Robert J.; Kozminski, Kirk; Li, Lilian Y.; Lockner, Jonathan W., 0000-0001-6148-0579; Lou, Jihong; Marra, Michelle T.; Mitchell, Lennert J.; Murray, Brion W.; Nieman, James A., 0000-0002-5087-0819; Noell, Stephen; Planken, Simon P., 0000-0001-8901-8992; Rowe, Thomas; Ryan, Kevin; Smith, George J.; Solowiej, James E.; Steppan, Claire M.; Taggart, Barbara Journal Of Medicinal Chemistry 2020
11074 10.1021/acs.jmedchem.9b01828 Zhang, Linlin; Lin, Daizong; Kusov, Yuri; Nian, Yong; Ma, Qingjun; Wang, Jiang; Von Brunn, Albrecht; Leyssen, Pieter; Lanko, Kristina; Neyts, Johan; De Wilde, Adriaan; Snijder, Eric J.; Liu, Hong, 0000-0002-0863-7853; Hilgenfeld, Rolf, 0000-0001-8850-2977 Journal Of Medicinal Chemistry 2020
11631 10.1021/acscombsci.0c00058 Targeting The Dimerization Of The Main Protease Of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy Goyal, Bhupesh, 0000-0002-0884-3622; Goyal, Deepti, 0000-0002-5352-9819 Acs Combinatorial Science 2020
11781 10.1021/acsmedchemlett.0c00521 Identification Of 14 Known Drugs As Inhibitors Of The Main Protease Of Sars-Cov-2 Ghahremanpour, Mohammad M., 0000-0002-1129-6041; Tirado-Rives, Julian, 0000-0001-7330-189X; Deshmukh, Maya; Ippolito, Joseph A.; Zhang, Chun-Hui; Cabeza De Vaca, Israel; Liosi, Maria-Elena; Anderson, Karen S., 0000-0003-3433-0780; Jorgensen, William L., 0000-0002-3993-9520 Acs Medicinal Chemistry Letters 2020
11976 10.1021/acsptsci.0c00108 Identification Of Sars-Cov-2 3Cl Protease Inhibitors By A Quantitative High-Throughput Screening Zhu, Wei; Xu, Miao; Chen, Catherine Z.; Guo, Hui; Shen, Min; Hu, Xin; Shinn, Paul; Klumpp-Thomas, Carleen; Michael, Samuel G.; Zheng, Wei, 0000-0003-1034-0757 Acs Pharmacology & Translational Science 2020
11977 10.1021/acsptsci.0c00130 Ebselen, Disulfiram, Carmofur, Px-12, Tideglusib, And Shikonin Are Nonspecific Promiscuous Sars-Cov-2 Main Protease Inhibitors Ma, Chunlong; Hu, Yanmei; Townsend, Julia Alma; Lagarias, Panagiotis I.; Marty, Michael Thomas, 0000-0001-8115-1772; Kolocouris, Antonios, 0000-0001-6110-1903; Wang, Jun, 0000-0002-4845-4621 Acs Pharmacology & Translational Science 2020
12728 10.1038/s41422-020-0356-z Boceprevir, Gc-376, And Calpain Inhibitors Ii, Xii Inhibit Sars-Cov-2 Viral Replication By Targeting The Viral Main Protease Ma, Chunlong, 0000-0002-5766-8189; Sacco, Michael Dominic; Hurst, Brett; Townsend, Julia Alma; Hu, Yanmei; Szeto, Tommy; Zhang, Xiujun; Tarbet, Bart; Marty, Michael Thomas; Chen, Yu; Wang, Jun Cell Research 2020
13329 10.1038/s41467-020-16954-7 Structural Plasticity Of Sars-Cov-2 3Cl Mpro Active Site Cavity Revealed By Room Temperature X-Ray Crystallography Nature Communications 2020
13357 10.1038/s41467-020-18096-2 Feline Coronavirus Drug Inhibits The Main Protease Of Sars-Cov-2 And Blocks Virus Replication Vuong, Wayne, 0000-0002-3439-8788; Khan, Muhammad Bashir, 0000-0002-4164-9573; Fischer, Conrad, 0000-0002-2289-010X; Arutyunova, Elena; Lamer, Tess, 0000-0002-1511-4540; Shields, Justin, 0000-0003-4701-4576; Saffran, Holly A.; Mckay, Ryan T., 0000-0002-0255-159X; Van Belkum, Marco J., 0000-0002-9296-6069; Joyce, Michael A., 0000-0002-9173-7299; Young, Howard S.; Tyrrell, D. Lorne, 0000-0002-0983-7267; Vederas, John C., 0000-0002-2996-0326; Lemieux, M. Joanne, 0000-0003-4745-9153 Nature Communications 2020
13363 10.1038/s41467-020-18233-x Both Boceprevir And Gc376 Efficaciously Inhibit Sars-Cov-2 By Targeting Its Main Protease Fu, Lifeng, 0000-0003-0431-5424; Ye, Fei; Feng, Yong; Yu, Feng; Wang, Qisheng; Wu, Yan; Zhao, Cheng; Sun, Huan; Huang, Baoying; Niu, Peihua; Song, Hao, 0000-0002-2811-0370; Shi, Yi, 0000-0002-3053-2687; Li, Xuebing, 0000-0001-8903-9793; Tan, Wenjie, 0000-0002-5963-1136; Qi, Jianxun; Gao, George Fu, 0000-0002-3869-615X Nature Communications 2020
13371 10.1038/s41467-020-18709-w Crystallographic And Electrophilic Fragment Screening Of The Sars-Cov-2 Main Protease Nature Communications 2020
13521 10.1038/s41557-020-0496-2 Crowdsourcing Drug Discovery For Pandemics Chodera, John; Lee, Alpha A.; London, Nir; Von Delft, Frank Nature Chemistry 2020
14384 10.1038/s41586-020-2223-y Structure Of Mpro From Sars-Cov-2 And Discovery Of Its Inhibitors Jin, Zhenming, 0000-0001-6448-820X; Du, Xiaoyu; Xu, Yechun, 0000-0002-1581-6155; Deng, Yongqiang; Liu, Meiqin; Zhao, Yao; Zhang, Bing; Li, Xiaofeng; Zhang, Leike; Peng, Chao; Duan, Yinkai; Yu, Jing; Wang, Lin; Yang, Kailin; Liu, Fengjiang; Jiang, Rendi; Yang, Xinglou; You, Tian; Liu, Xiaoce; Yang, Xiuna; Bai, Fang; Liu, Hong; Liu, Xiang; Guddat, Luke W.; Xu, Wenqing; Xiao, Gengfu; Qin, Chengfeng; Shi, Zhengli, 0000-0001-8089-163X; Jiang, Hualiang, 0000-0003-0656-6315; Rao, Zihe, 0000-0001-9866-2384; Yang, Haitao, 0000-0002-1875-3268 Nature 2020
14606 10.1038/s41589-020-00689-z Sars-Cov-2 Mpro Inhibitors And Activity-Based Probes For Patient-Sample Imaging Rut, Wioletta, 0000-0003-1261-5566; Groborz, Katarzyna; Zhang, Linlin; Sun, Xinyuanyuan; Zmudzinski, Mikolaj, 0000-0002-9792-9160; Pawlik, Bartlomiej, 0000-0002-8803-1033; Wang, Xinyu; Jochmans, Dirk, 0000-0002-9265-6028; Neyts, Johan; M<U+0142>ynarski, Wojciech, 0000-0003-2714-5851; Hilgenfeld, Rolf; Drag, Marcin, 0000-0001-8510-1967 Nature Chemical Biology 2020
14876 10.1038/s41594-020-0440-6 Structural Basis For The Inhibition Of Sars-Cov-2 Main Protease By Antineoplastic Drug Carmofur Jin, Zhenming, 0000-0001-6448-820X; Zhao, Yao; Sun, Yuan, 0000-0001-8244-7436; Zhang, Bing; Wang, Haofeng; Wu, Yan; Zhu, Yan; Zhu, Chen; Hu, Tianyu; Du, Xiaoyu, 0000-0002-8415-8686; Duan, Yinkai; Yu, Jing; Yang, Xiaobao; Yang, Xiuna; Yang, Kailin; Liu, Xiang, 0000-0001-5498-6942; Guddat, Luke W.; Xiao, Gengfu; Zhang, Leike, 0000-0002-2593-2571; Yang, Haitao, 0000-0002-1875-3268; Rao, Zihe Nature Structural & Molecular Biology 2020
15751 10.1039/d0sc02823a Revealing The Molecular Mechanisms Of Proteolysis Of Sars-Cov-2 Mproby Qm/Mm Computational Methods <U+015A>widerek, Katarzyna, 0000-0002-7528-1551; Moliner, Vicent, 0000-0002-3665-3391 Chemical Science 2020
18727 10.1126/sciadv.abe0751 Structure And Inhibition Of The Sars-Cov-2 Main Protease Reveal Strategy For Developing Dual Inhibitors Against M Pro And Cathepsin L Sacco, Michael Dominic, 0000-0001-5930-7363; Ma, Chunlong, 0000-0002-5766-8189; Lagarias, Panagiotis; Gao, Ang; Townsend, Julia Alma; Meng, Xiangzhi; Dube, Peter; Zhang, Xiujun; Hu, Yanmei; Kitamura, Naoya; Hurst, Brett, 0000-0003-1025-5878; Tarbet, Bart, 0000-0002-4255-9094; Marty, Michael Thomas, 0000-0001-8115-1772; Kolocouris, Antonios; Xiang, Yan; Chen, Yu, 0000-0002-5115-3600; Wang, Jun, 0000-0002-4845-4621 Science Advances 2020
18996 10.1126/science.abb3405 Zhang, Linlin, 0000-0002-4642-9617; Lin, Daizong, 0000-0002-4271-5739; Sun, Xinyuanyuan, 0000-0002-2761-2862; Curth, Ute; Drosten, Christian, 0000-0001-7923-0519; Sauerhering, Lucie, 0000-0001-5487-3243; Becker, Stephan; Rox, Katharina, 0000-0002-8020-1384; Hilgenfeld, Rolf, 0000-0001-8850-2977 Science 2020
18998 10.1126/science.abb4489 Structure-Based Design Of Antiviral Drug Candidates Targeting The Sars-Cov-2 Main Protease Dai, Wenhao, 0000-0001-8508-7130; Zhang, Bing, 0000-0001-8556-8049; Jiang, Xia-Ming; Su, Haixia, 0000-0002-7174-3851; Li, Jian; Zhao, Yao, 0000-0002-2932-2164; Xie, Xiong; Jin, Zhenming, 0000-0001-6448-820X; Peng, Jingjing; Liu, Fengjiang, 0000-0002-9400-308X; Li, Chunpu; Li, You; Bai, Fang, 0000-0003-1468-5568; Wang, Haofeng, 0000-0001-8175-5621; Cheng, Xi, 0000-0003-3081-3750; Cen, Xiaobo; Hu, Shulei; Yang, Xiuna; Wang, Jiang, 0000-0003-1705-4905; Liu, Xiang, 0000-0001-5498-6942; Xiao, Gengfu; Jiang, Hualiang, 0000-0003-0656-6315; Rao, Zihe, 0000-0001-9866-2384; Zhang, Lei-Ke; Xu, Yechun, 0000-0002-3120-3578; Yang, Haitao, 0000-0002-1875-3268; Liu, Hong, 0000-0003-3685-6268 Science 2020
19101 10.1126/scitranslmed.abc5332 3C-Like Protease Inhibitors Block Coronavirus Replication In Vitro And Improve Survival In Mers-Cov<U+2013>Infected Mice Rathnayake, Athri D., 0000-0003-2588-7624; Zheng, Jian, 0000-0003-0909-128X; Kim, Yunjeong, 0000-0002-2977-4400; Perera, Krishani Dinali, 0000-0002-3778-4975; Mackin, Samantha; Meyerholz, David K., 0000-0003-1552-3253; Kashipathy, Maithri M., 0000-0003-0435-989X; Battaile, Kevin P., 0000-0003-0833-3259; Lovell, Scott, 0000-0002-3215-4472; Perlman, Stanley, 0000-0003-4213-2354; Groutas, William C., 0000-0001-5248-7912; Chang, Kyeong-Ok, 0000-0002-4435-3751 Science Translational Medicine 2020
21186 10.3390/ijms21093099 Structural And Evolutionary Analysis Indicate That The Sars-Cov-2 Mpro Is A Challenging Target For Small-Molecule Inhibitor Design Bzowka, Maria, 0000-0001-6802-8753; Mitusi<U+0144>ska, Karolina, 0000-0002-0183-0845; Raczy<U+0144>ska, Agata; Samol, Aleksandra; Tuszy<U+0144>ski, Jack A., 0000-0001-9976-0429; Gora, Artur, 0000-0003-2530-6957 International Journal Of Molecular Sciences 2020